APC has various meanings in the Biochemistry category. Discover the full forms, definitions, and usage contexts of APC in Biochemistry.
An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during mitosis through ubiquitination of specific cell cycle proteins. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the placenta, crystalline lens, and skeletal muscle, and in regulation of postmitotic neuronal plasticity and excitability.
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