What does ESFTS stand for?

Ewing Sarcoma Family of Tumors

Ewing sarcoma family of tumors (ESFT) refers to a group of rare and aggressive cancers that primarily affect children and young adults. These tumors arise from the bones or soft tissues, such as muscles or nerves. ESFT most commonly occurs in the long bones of the arms and legs, pelvis, chest wall, or spine.

ESFT is named after Dr. James Ewing, an American pathologist who first described these tumors in the early 20th century. It is characterized by a specific chromosomal translocation known as the EWSR1-FLI1 fusion gene, which is present in the majority of cases. This genetic abnormality leads to uncontrolled cell growth and the formation of tumors.

Ewing'S Sarcoma Family Tumors