What does PH2 stand for?

Player'S Handbook, 2Nd

Primary Hyperoxaluria Type 2

Primary Hyperoxaluria Type 2 (PH2) is a rare genetic disorder characterized by the overproduction of oxalate, a substance that, when accumulated in the body, can lead to the formation of kidney stones and other renal complications. This condition is caused by mutations in the GRHPR gene, which plays a crucial role in the metabolism of glyoxylate. Without proper function of this gene, glyoxylate is converted into oxalate instead of being recycled or excreted, leading to its accumulation.

The management of PH2 involves a multidisciplinary approach, including dietary modifications to reduce oxalate intake, increased fluid intake to dilute urine, and in some cases, pharmacological treatments to decrease oxalate production. Early diagnosis and intervention are critical to prevent the progression of kidney damage and other systemic complications associated with oxalate deposition. Research into gene therapy and other novel treatments offers hope for more effective management of this condition in the future.

Player'S Handbook, 2

Players Handbook 2

PHOTOGRAPHER'S MATE PETTY OFFICER 2ND CLASS