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Spot Forming Units (SFU) are a quantitative measure used in immunology to assess the frequency of antigen-specific T cells in a given sample. This method is pivotal in vaccine development and infectious disease research, providing insights into cellular immune responses. The SFU assay involves stimulating T cells with specific antigens and then enumerating the resulting spots, each representing a single reactive T cell.
The application of SFU extends beyond research, playing a critical role in clinical diagnostics and therapeutic monitoring. For instance, in tuberculosis and HIV research, SFU measurements help evaluate the efficacy of new treatments. The precision and reproducibility of the SFU assay make it a cornerstone in immunology, facilitating advancements in understanding immune system dynamics and pathogen interactions.
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