What does SLUD stand for?

Salivation, Lacrimation, Urination, Defecation

The term SLUD, standing for Salivation, Lacrimation, Urination, and Defecation, is a mnemonic used to remember the symptoms associated with excessive cholinergic activity, often resulting from exposure to certain toxins or drugs that inhibit acetylcholinesterase. This condition leads to an overstimulation of the parasympathetic nervous system, manifesting in these specific physiological responses. Understanding these symptoms is crucial for healthcare professionals to quickly identify and treat cholinergic crisis, which can be life-threatening if not addressed promptly.

The SLUD syndrome is particularly relevant in the context of anticholinergic drugs, which are used to treat a variety of conditions by blocking the action of acetylcholine in the central and peripheral nervous systems. These drugs can cause the opposite effects of SLUD, such as dry mouth and constipation, highlighting the delicate balance of cholinergic activity in the body. The study of SLUD symptoms not only aids in the diagnosis of cholinergic excess but also underscores the importance of monitoring for anticholinergic side effects in patients receiving such medications.