What does TOP stand for?

Also known as: top.

TOP stands for various terms. Discover the full forms, meanings, and possible interpretations of TOP across different fields and industries.

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Thimet Oligopeptidase

Thimet Oligopeptidase (TOP) is a metallopeptidase that plays a crucial role in the metabolism of bioactive peptides, including those involved in blood pressure regulation and pain modulation. It is characterized by its ability to cleave small peptides, making it a key enzyme in peptide turnover and signaling. The enzyme's activity is dependent on zinc ions, highlighting its classification within the metallopeptidase family.

In the medical field, TOP's involvement in peptide metabolism has made it a subject of interest for therapeutic targeting, particularly in conditions like hypertension and chronic pain. Research into inhibitors of TOP aims to modulate its activity to achieve desired therapeutic outcomes. The enzyme's specificity for oligopeptides distinguishes it from other peptidases, offering a unique avenue for drug development.

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How is TOP used?

  • In the study of hypertension, researchers focus on TOP (Thimet Oligopeptidase) for its role in metabolizing peptides that regulate blood pressure, highlighting its medical significance.

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